Hoffenheim welcome Dortmund in a Friday Bundesliga fixture at the Prezero Arena.
The hosts will be in search for their fifth consecutive win in the Bundesliga after wins over Union Berlin, Koln, Wolfsburg and Hedenheim.
Hoffenheim, despite a 2-1 opening weekend loss to Freiburg, holds a one-point lead over their opponents thanks to four consecutive victories.
All credit for the hosts will go to Coach Pellegrino Matarazzo who has been able to build a strong foundation since his appointment in February.
Dortmund on the other hand, are unbeaten with three wins and two draws from their first five fixtures.
The Visitors, away from their 2-0 loss to PSG in the opening Champions League fixture, has rebounded with wins against Freiburg and Wolfsburg.
Marco Reus, the club captain, made a noteworthy return from injury by scoring in both victories.
Hoffenheim may be without several players, including Florian Grillitsch and Stanley Nsoki while loanee Wout Weghorst is also ruled out.
Dortmund will also be missing a couple of players including Marcel Sabitzer and Thomas Meunier due to injuries, and they may also opt to rest players ahead of the home match against AC Milan in the Champions League on Wednesday.
It’s difficult for Dortmund to win this one, a win for Hoffenheim looks within their reach, but a 1X looks juicy at 1.79 and SAFER.
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